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Seminars in oncology · Jun 1999
ReviewDocetaxel (Taxotere) in combination with platinum-based regimens in non-small cell lung cancer: results and future developments.
- C P Belani.
- Lung Cancer Program, the University of Pittsburgh Cancer Institute, PA 15213, USA.
- Semin. Oncol. 1999 Jun 1; 26 (3 Suppl 10): 15-8.
AbstractThe combination of docetaxel (Taxotere; Rhône-Poulenc Rorer, Antony, France) with cisplatin is feasible, has manageable toxicity, and is active in stage IIIB/IV non-small cell lung cancer. The four phase II trials completed to date show response rates ranging from 32% to 48% and median survival durations of 8 to 13 months. Based on these results, regimens combining 75 to 100 mg/m2 docetaxel with 75 to 100 mg/m2 cisplatin are now being assessed in randomized phase III comparisons with platinum-containing combinations. The combination of docetaxel and carboplatin also has promising activity, with response rates of 48% (1 complete response and 12 partial responses) seen in 27 evaluable patients. Overall, this combination is also well tolerated. However, it will be necessary to use both docetaxel/platinum regimens at earlier stages in the disease if a significant impact is to be made on survival.
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