• Angiology · Oct 2016

    CHA2DS2-VASc Score is a Predictor of No-Reflow in Patients With ST-Segment Elevation Myocardial Infarction Who Underwent Primary Percutaneous Intervention.

    • Gokturk Ipek, Tolga Onuk, Mehmet B Karatas, Baris Gungor, Altug Osken, Muhammed Keskin, Ahmet Oz, Ozan Tanik, Mert Ilker Hayiroglu, Hale Yilmaz Yaka, Recep Ozturk, and Osman Bolca.
    • Brigham and Women's Hospital, Boston, MA, USA Department of Cardiology, Siyami Ersek Cardiothoracic Surgery Center, Istanbul, Turkey gipek@partners.org.
    • Angiology. 2016 Oct 1; 67 (9): 840-5.

    AbstractThrombosis and distal embolization play crucial role in the etiology of no-reflow. CHA2DS2-VASc score is used to estimate the risk of thromboembolism in patients with atrial fibrillation. We tested the hypothesis that CHA2DS2-VASc can predict no-reflow among patients who underwent primary percutaneous coronary intervention (PCI). A total number of 2375 consecutive patients with ST-segment elevation myocardial infarction were assessed for the study. Patients were divided into 2 groups as no-reflow (n = 111) and control (n = 1670) groups according to post-PCI no-reflow status. CHA2DS2-VASc scores were calculated for all patients. CHA2DS2-VASc scores were significantly higher in the no-reflow group compared to the control group. After a multivariate regression analysis, CHA2DS2-VASc score remained as an independent predictor (odds ratio: 1.58, 95% confidence interval: 1.33-1,88, P < .001) of no-reflow. Receiver-operating characteristics analysis revealed the cutoff value of CHA2DS2-VASc score ≥2 as a predictor of no-reflow with a sensitivity of 66% and a specificity of 59%. Moreover, in-hospital mortality was also associated with significantly higher CHA2DS2-VASc scores. In conclusion, CHA2DS2-VASc score is associated with higher risk of no-reflow and in-hospital mortality rates in patients who underwent primary PCI.© The Author(s) 2015.

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