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- J Tomiyama, K Yano, S Uchino, T Ito, H Kudo, J Irimajiri, H Ohkubo, A Kanazawa, and Y Kawahara.
- Department of Internal Medicine, Tokyo Metropolitan Bokuto General Hospital.
- Rinsho Ketsueki. 1997 Mar 1; 38 (3): 231-3.
AbstractWe report a 45-year-old male with chronic myelogenous leukemia (CML) who experienced skin ulcers of the left lateral malleolus and dorsum of both feet. He had been treated with hydroxyurea (HU) for 2 years. His leg ulcers improved after HU was discontinued. Skin biopsy of the ulcerated lesion revealed that the lesion is compatible with small vessel vasculitis, but circulating immune complexes (C1q, anti-C3d antibody) were negative. Although the precise mechanism of the skin ulcer is unknown, we must take into consideration the skin changes were secondary to hydroxyurea therapy in myeloproliferative disorders.
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