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- Hirofumi Yamamoto, Masataka Oda, Mayo Nakano, Naoyuki Watanabe, Kenta Yabiku, Masahiro Shibutani, Masahisa Inoue, Hiroshi Imagawa, Masahiro Nagahama, Seiichiro Himeno, Kojun Setsu, Jun Sakurai, and Mugio Nishizawa.
- Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan. hirofumi@ph.bunri-u.ac.jp
- J. Med. Chem. 2013 Jan 10; 56 (1): 381-5.
AbstractVizantin, 6,6'-bis-O-(3-nonyldodecanoyl)-α,α'-trehalose, was developed as a safe immunostimulator on the basis of a structure-activity relationship (SAR) study with trehalose 6,6'-dicorynomycolate (TDCM). It was possible to synthesize vizantin on a large scale more easily than in the case of TDCM, and the compound exhibited more potent prophylactic effect on experimental lung metastasis of B16-F0 melanoma cells. Because vizantin stimulated human macrophages, it is a promising candidate for clinical application.
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