• Y Zhang, Y-J Liu, T Liu, H Zhang, and S-J Yang.
• Department of Cardiology, Tianjin Chest Hospital, Tianjin, China. yujieliu2012@126.com.
• Eur Rev Med Pharmacol Sci. 2016 Jan 1; 20 (2): 323-9.

ObjectivePrevious studies have demonstrated that microRNA-21 (miR-21) is involved in the pathogenesis of myocardium infarction and cardiac fibrosis; the present study aimed to investigate its potential role in the diagnosis of acute myocardium infarction (AMI).Patients And MethodsA cohort of patients with AMI and angina pectoris (AP) were studied, plasma miR-21 level was determined by Realtime-PCR.ResultsWe found that the plasma miR-21 level was significantly elevated in patients with AMI compared with those with AP or healthy people. Further studies demonstrated the correlation of miR-21 and several traditional markers such as creatine kinase (CK), creatine kinase-MB (CK-MB) and troponin I (cTnI) in study subjects. Finally, receiver-operator characteristic curve (ROC) analysis showed that miR-21 has similar diagnostic ability compared with CK, CK-MB and cTnI.ConclusionsPlasma miR-21 may be a novel biomarker for the diagnosis of AMI. Our study may also provide implications for the development of new biomarkers.

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