• Romulo Maciel Lustosa, Diogo de Vasconcelos Macedo, IwakiLilian Cristina VessoniLCDepartment of Dentistry, State University of Maringá, Maringá, Paraná, Brazil., Elen de Souza Tolentino, Paulo Norberto Hasse, Giordano Bruno de Oliveira Marson, and Iwaki FilhoLiogiLDepartment of Dentistry, State University of Maringá, Maringá, Paraná, Brazil..
• Department of Dentistry, State University of Maringá, Maringá, Paraná, Brazil. Electronic address: romulomlustosa@gmail.com.
• J Craniomaxillofac Surg. 2015 Oct 1; 43 (8): 1553-60.

AbstractRecombinant human morphogenetic protein (rhBMP) is a graft alternative for extensive mandibular reconstruction after tumor resections. However, the feasibility of rhBMP-2 to receive osseointegrated implants and prosthetic rehabilitation has been rarely reported. This study reports on a case of an extensive solid ameloblastoma along the mandibular body. The treatment consisted of resection followed by off-label use of rhBMP type 2 associated with bovine bone xenograft. Eleven months postoperatively, the patient was prosthetically rehabilitated with dental implants, without evidence of resorption or complications. The literature on mandibular reconstructions using rhBMP and their feasibility for future osseointegrated implant placement was also reviewed. Based on the presented case, the association between rhBMP-2 and a bovine bone xenograft could be considered a feasible option for the reconstruction and rehabilitation of large mandibular defects after tumor resection. According to the literature, the use of rhBMP as a graft material is encouraging, with good clinical outcome. However, there are no long-term studies demonstrating success and survival rates of implants placed in these grafts. Future investigations will be required to ascertain the long-term survival of implants in areas grafted with rhBMP. Also, there is a lack of information regarding the prosthetic rehabilitation of these patients. Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

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