• Gan To Kagaku Ryoho · May 2001

    Review

    [Tyrosine kinase inhibitor--hematological malignancies].

    • R Ohno.
    • Aichi Cancer Center.
    • Gan To Kagaku Ryoho. 2001 May 1; 28 (5): 601-7.

    AbstractSTI571 selectively inhibits the ABL-tyrosine kinase, the activity of which is activated by the formation of chimeric BCR/ABL. A phase I study in the USA showed STI571 to be remarkably effective in cases of interferon-refractory chronic myeloid leukemia, with almost no adverse effects. STI571 may become the first choice drug prior to stem cell transplantation and interferon treatment.

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