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- Sun M Lim, Hee-Jung An, Hyung S Park, Hyeong J Kwon, Y KimEunE, Jin Hur, and Yong W Moon.
- Medical Oncology, Department of Internal Medicine Department of Pathology, CHA Bundang Medical Center, CHA University, Seongnam Division of Medical Oncology, Department of Internal Medicine, Department of Pathology Division of Pulmonology, Department of Internal Medicine Department of Radiology, Yonsei University College of Medicine, Seoul, Korea.
- Medicine (Baltimore). 2018 Aug 1; 97 (31): e11646.
RationaleEchinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), a distinct molecular entity, is highly sensitive to ALK tyrosine kinase inhibitors (TKIs) such as crizotinib or ceritinib. Interstitial lung disease is a rare (1.2%) pulmonary toxicity that can result from ALK TKIs, however, organizing pneumonia has not been reported to date.Patient ConcernsA 45-year-old Korean female with ALK-rearranged metastatic lung adenocarcinoma underwent ceritinib treatment and exhibited a partial response, until she developed organizing pneumonia resembling disease progression.DiagnosesMultiple rebiopsies confirmed the involvement of organizing pneumonia in the pathology.InterventionsCeritinib was stopped and the patient was treated with intravenous antibiotics followed by oral antibiotics for two weeks.OutcomesAfter recovering from organizing pneumonia, ceritinib was successfully rechallenged and the patient attained a complete response.LessonsWhen a new mass-like lesion develops in the lungs of responding patients, benign lung conditions, including organizing pneumonia should be considered in differential diagnoses.
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