• Int. J. Radiat. Oncol. Biol. Phys. · Dec 2007

    Multicenter Study

    Duodenal adenocarcinoma: patterns of failure after resection and the role of chemoradiotherapy.

    • Chris R Kelsey, John W Nelson, Christopher G Willett, Junzo P Chino, Robert W Clough, Johanna C Bendell, Douglas S Tyler, Herbert I Hurwitz, Michael A Morse, Bryan M Clary, Theodore N Pappas, and Brian G Czito.
    • Department of Radiation Oncology, Division of Medical Oncology and Transplantation, Duke University Medical Center, Durham, NC 27710, USA. kelse003@mc.duke.edu
    • Int. J. Radiat. Oncol. Biol. Phys. 2007 Dec 1; 69 (5): 1436-41.

    PurposeTo report patterns of disease recurrence after resection of adenocarcinoma of the duodenum and compare outcomes between patients undergoing surgery only vs. surgery with concurrent chemotherapy and radiation therapy (CT-RT).Methods And MaterialsThis was a retrospective analysis of all patients undergoing potentially curative therapy for adenocarcinoma of the duodenum at Duke University Medical Center and affiliated hospitals between 1975 and 2005. Overall survival (OS), disease-free survival (DFS), and local control (LC) were estimated using the Kaplan-Meier method. Univariate regression analysis evaluated the effect of CT-RT on clinical endpoints.ResultsThirty-two patients were identified (23 M, 9 F). Median age was 60 years (range, 32-77 years). Surgery alone was performed in 16 patients. An additional 16 patients received either preoperative (n = 11) or postoperative (n = 5) CT-RT. Median RT dose was 50.4 Gy (range, 12.6-54 Gy). All patients treated with RT also received concurrent 5-fluorouracil-based CT. Two patients treated preoperatively had a pathologic complete response (18%), and none had involved lymph nodes at resection. Five-year OS, DFS, and LC for the entire group were 48%, 47%, and 55%, respectively. Five-year survival did not differ between patients receiving CT-RT vs. surgery alone (57% vs. 44%, p = 0.42). However, in patients undergoing R0 resection, CT-RT appeared to improve OS (5-year 83% vs. 53%, p = 0.07).ConclusionsLocal failure after surgery alone is high. Given the patterns of relapse with surgery alone and favorable outcomes in patients undergoing complete resection with CT-RT, the use of CT-RT in selected patients should be considered.

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