• Georgina Jones, Crispin Jenkinson, and Stephen Kennedy.
• Nuffield Department of Obstetrics and Gynaecology, University of Oxford, United Kingdom. g.l.jones@sheffield.ac.uk
• Qual Life Res. 2004 Apr 1; 13 (3): 705-13.

ObjectivesTo evaluate the sensitivity to change of the Endometriosis Health Profile-30 (EHP-30) questionnaire.SettingThe Women's Center, John Radcliffe Hospital, Oxford.DesignPostal survey to 66 women undergoing conservative surgery for the treatment of endometriosis-associated pain. The EHP-30 and the Short Form-36 (SF-36) were administered 2 weeks before the operation, and 4 months post-operatively. At T2 a transition question was included to evaluate changes in patients health status. To evaluate responsiveness effect sizes, standardised response means, the index of responsiveness and the minimally and clinically important differences were calculated.ResultsForty (66.6%) patients returned the questionnaires at time 1 and 2. Overall less responsive effect size scores were found for the SF-36 (0.1-0.5) compared to the EHP-30 (-0.1-1.1) for all patients who had undergone treatment. Minimally important differences and the index of responsiveness were overall higher for the EHP-30 (0.4-2.0) compared to the SF-36 (0.1-1.0). Change scores for four of the five scales were significantly correlated with women's responses to the transition question.ConclusionsResults suggest that the EHP-30 is sensitive to change. Its application in clinical trials should prove beneficial in assessing the impact of medical and surgical interventions upon quality of life for women with endometriosis.

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