• Expert Opin Investig Drugs · Jun 2010

    Review

    BIBF 1120 for the treatment of non-small cell lung cancer.

    • Martin Reck.
    • Hospital Grosshansdorf, Department of Thoracic Oncology, Grosshansdorf, Germany. Dr.Martin.Reck@web.de
    • Expert Opin Investig Drugs. 2010 Jun 1; 19 (6): 789-94.

    Importance Of The FieldFor patients with advanced non-small cell lung cancer (NSCLC), chemotherapy offers modest benefits and outcomes are poor. Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is a fundamental process for tumor growth and development. Tumor vasculature is therefore emerging as an important target for cancer therapy.Areas Covered In This ReviewThis expert review will briefly discuss several antiangiogenic agents approved for the treatment of NSCLC, including many more currently being investigated in clinical trials, such as neutralizing antibodies of pro-angiogenic factors and inhibitors of their tyrosine kinase receptors. This review will also provide an overview of BIBF 1120, a novel, potent, triple angiokinase inhibitor that simultaneously acts on three receptor families involved in blood vessel formation: vascular endothelial growth factor receptors, platelet-derived growth factor receptors and fibroblast growth factor receptors.What The Reader Will GainExpert opinion on the promising results obtained in Phase I studies demonstrating that BIBF 1120 is well tolerated in patients with advanced solid tumors will be provided. Further experience from a Phase II monotherapy trial also indicates promising efficacy and a favorable safety profile in patients with relapsed advanced NSCLC.Take Home MessageBased on these data, the BIBF 1120 Phase III clinical development program is currently underway and will be discussed in further detail.

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