• Am J Addict · Jul 2019

    Case Reports

    Rapid micro-induction of buprenorphine/naloxone for opioid use disorder in an inpatient setting: A case series.

    • Sukhpreet Klaire, Rebecca Zivanovic, Skye Pamela Barbic, Raman Sandhu, Nickie Mathew, and Pouya Azar.
    • British Columbia Centre on Substance Use, Vancouver, Canadian Province, Canada.
    • Am J Addict. 2019 Jul 1; 28 (4): 262-265.

    Background And ObjectivesBuprenorphine/naloxone has been shown to be effective in the treatment of opioid use disorder. Due to its pharmacological properties, induction can be challenging, time-consuming, and result in sudden onset of withdrawal symptoms.MethodsRetrospective case series (n = 2).ResultsTwo patients with opioid use disorder were successfully started on buprenorphine/naloxone using a rapid micro-induction technique that did not cause precipitated withdrawal or require preceding cessation of other opioids.Discussion And ConclusionsThese cases provide an alternative method for starting buprenorphine/naloxone that offers unique benefits compared to protocols previously described in the literature.Scientific SignificanceThis method can be used to minimize barriers to opioid agonist therapy. (Am J Addict 2019;28:262-265).© 2019 American Academy of Addiction Psychiatry.

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