• Critical care clinics · Oct 1997

    Review

    Poisoning by sodium channel blocking agents.

    • P F Kolecki and S C Curry.
    • Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, Arizona, USA.
    • Crit Care Clin. 1997 Oct 1; 13 (4): 829-48.

    AbstractPoisoning by drugs that block voltage-gated sodium channels produces intraventricular conduction defects, myocardial depression, bradycardia, and ventricular arrhythmias. Human and animal reports suggest that hypertonic sodium bicarbonate may be effective therapy for numerous agents possessing sodium channel blocking properties, including cocaine, quinidine, procainamide, flecainide, mexiletine, bupivacaine, and others.

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