• Eur J Gynaecol Oncol · Jan 2000

    Case Reports

    Megestrol-induced clinical adrenal insufficiency.

    • A Goodman and E Cagliero.
    • Harvard Medical School Massachusetts General Hospital, Department of Obstetrics and Gynecology, Boston 02114, USA.
    • Eur J Gynaecol Oncol. 2000 Jan 1; 21 (2): 117-8.

    ObjectiveTo describe a case of megestrol-induced adrenal insufficiency.MethodsA patient who received megestrol and then developed pituitary-adrenal axis abnormalities is described. The literature is reviewed.ResultsThe patient developed megestrol-induced Cushingoid features. She developed adrenal insufficiency when megestrol was stopped.ConclusionMegestrol can induce alterations of the pituitary-adrenal axis in some patients. It is important to consider a diagnosis of adrenal insufficiency in patients with symptoms of fatigue, hypotension, and asthenia who have been treated with megestrol.

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