• Felipe von Glehn, Sven Jarius, Rodrigo Pessoa Cavalcanti Lira, Maria Carolina Alves Ferreira, Fadua H Ribeiro von Glehn, Stella Maris Costa E Castro, Guilherme Coco Beltramini, Felipe Pg Bergo, Alessandro S Farias, Carlos Otávio Brandão, Brigitte Wildemann, Benito P Damasceno, Fernando Cendes, Leonilda M B Santos, and Clarissa Lin Yasuda.
• Neuroimmunology Unit, Department of Genetics, Evolution and Bioagents, University of Campinas, Brazil Laboratory of Neuroimaging, Department of Neurology, University of Campinas, Brazil fglehn@terra.com.br leonilda@unicamp.br yasuda.clarissa@gmail.com.
• Mult. Scler. 2014 Aug 1; 20 (9): 1189-97.

BackgroundAlthough aquaporin-4 (AQP4) is widely expressed in the human brain cortex, lesions are rare in neuromyelitis optica (NMO) spectrum disorders (NMOSD). Recently, however, several studies have demonstrated occult structural brain atrophy in NMO.ObjectiveThis study aims to investigate magnetic resonance imaging (MRI) patterns of gray matter (GM) and white matter (WM) abnormalities in patients with NMOSD and to assess the visual pathway integrity during disease duration correlation of the retinal nerve fiber layer (RNFL) and pericalcarine cortex thickness.MethodsTwenty-one patients with NMOSD and 34 matched healthy controls underwent both high-field MRI (3T) high-resolution T1-weighted and diffusion-tensor MRI. Voxel-based morphometry, cortical analyses (Freesurfer) and diffusion-tensor imaging (DTI) analyses (TBSS-FSL) were used to investigate brain abnormalities. In addition, RNFL measurement by optic-coherence tomography (OCT) was performed.ResultsWe demonstrate that NMOSD is associated with GM and WM atrophy, encompassing more frequently the motor, sensory and visual pathways, and that the extent of GM atrophy correlates with disease duration. Furthermore, we demonstrate for the first time a correlation between RNFL and pericalcarine cortical thickness, with cortical atrophy evolving over the course of disease.ConclusionsOur findings indicate a role for retrograde and anterograde neurodegeneration in GM atrophy in NMOSD. However, the presence atrophy encompassing almost all lobes suggests that additional pathomechanisms might also be involved.© The Author(s) 2014.

25 keywords...

hide…