• Oral Oncol · Jan 2013

    Comparative Study

    Scintigraphic assessment of salivary function after intensity-modulated radiotherapy for head and neck cancer: correlations with parotid dose and quality of life.

    • Wen-Cheng Chen, Chia-Hsuan Lai, Tsair-Fwu Lee, Chao-Hsiung Hung, Kuo-Chi Liu, Ming-Fong Tsai, Wen-Hung Wang, Hungcheng Chen, Fu-Ming Fang, and Miao-Fen Chen.
    • Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiayi, and Chang Gung University, College of Medicine, Tao-yuan, Taiwan.
    • Oral Oncol. 2013 Jan 1; 49 (1): 42-8.

    ObjectiveWe investigated salivary function using quantitative scintigraphy and sought to identify functional correlations between parotid dose and quality of life (QoL) for head and neck cancer (HNC) patients receiving intensity-modulated radiotherapy (IMRT).Materials And MethodsBetween August, 2007 and June, 2008, 31 patients treated IMRT for HNC were enrolled in this prospective study. Salivary excretion function (SEF) was previously measured by salivary scintigraphy at annual intervals for 2 years after IMRT. A dose-volume histogram of each parotid gland was calculated, and the normal tissue complication probability (NTCP) was used to determine the tolerance dose. QoL was longitudinally assessed by the EORTC QLQ-C30 and H&N35 questionnaires prior to RT, and at one, three, 12 and 24 months after RT.ResultsA significant correlation was found between the reduction of SEF and the mean parotid dose measured at 1 year (correlation coefficient, R(2)=0.651) and 2 years (R(2)=0.310) after IMRT (p<0.001). The TD(50) of the parotid gland at 1 year after IMRT is 43.6 Gy, comparable to results from western countries. We further found that contralateral parotid and submandibular gland function preservation was correlated with reduced sticky saliva and a better QoL compared to the functional preservation of both parotid glands, as determined by the EORTC QLQ-H&N35 questionnaire.ConclusionA significant correlation was found between the reduction of SEF and the mean parotid dose. Preservation of contralateral parotid and submandibular gland function predicts a better QoL compared to preservation of the function of both parotid glands.Copyright © 2012 Elsevier Ltd. All rights reserved.

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