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Zhongguo Fei Ai Za Zhi · Jul 2019
Review[Progress in Clinical Researches of PD-1/PD-L1 Checkpoint Inhibitor for Non-small Cell Lung Cancer].
- Sixuan Wu, Chunhong Hu, Fang Wu, Yuanqiang Wu, and Ping Liu.
- Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Zhongguo Fei Ai Za Zhi. 2019 Jul 20; 22 (7): 440-448.
AbstractNon-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer. In recent years, immunotherapy has developed rapidly. Immune checkpoint inhibitors, especially programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors have made a breakthrough in the treatment of NSCLC and changed the treatment pattern for NSCLC. Immunological checkpoint inhibitors targeting PD-1/PD-L1 are beneficial to patients, both in the first-line and second-line treatment of advanced NSCLC, in the adjuvant treatment of locally-advanced NSCLC, and in the neoadjuvant therapy of early NSCLC, which show an important role in the comprehensive treatment of NSCLC. This article reviews the clinical research progress of immunological checkpoint inhibitors targeting PD-1/PD-L1 in NSCLC. .
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