• Hwong-Ruey Leow, Siew-Mooi Ching, Ramanujam Sujarita, Choon-Fong Yap, Yook-Chin Chia, Shiaw-Hooi Ho, Suresh Sithambaram, Huck-Joo Tan, Khean-Lee Goh, and Sanjiv Mahadeva.
• Division of Gastroenterology, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
• J Dig Dis. 2014 Nov 1; 15 (11): 591-6.

ObjectiveTo develop and validate a Mandarin version of the Leeds Dyspepsia Questionnaire (M-LDQ) in Asian patients with dyspepsia.MethodsThe M-LDQ was developed according to standardized methods. The validity, internal consistency, test-retest reliability and responsiveness of the instrument were evaluated in both primary and secondary care patients.ResultsA total of 184 patients (mean age 54.0 ± 15.8 years, of whom 59% were women and 72.3% of whom had at least secondary level education) were recruited between August 2012 and March 2013, from both primary (n = 100) and secondary care clinics (n = 84). Both the internal consistency of all components of the M-LDQ (Cronbach's α 0.79) and test-retest reliability (Spearman's correlation coefficient 0.78) were good. The M-LDQ was valid in diagnosing dyspepsia in primary care (area under the receiver operating characteristics curve 0.84) and was able to discriminate between secondary and primary care patients (median cumulative LDQ score 13.0 vs 3.0, P < 0.0001). Among eight patients with organic dyspepsia, the median M-LDQ score reduced significantly from 21.0 (pretreatment) to 9.5 (4 weeks post-treatment) (P < 0.0001).ConclusionThe M-LDQ is a valid and responsive instrument for assessing ethnic Chinese adults with dyspepsia.© 2014 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

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