• Oncology nursing forum · Jun 1992

    Management of chemotherapy-related nausea and vomiting using a serotonin antagonist.

    • A P Egan, J R Taggart, and C M Bender.
    • Forbes Regional Health Center, Monroeville, PA.
    • Oncol Nurs Forum. 1992 Jun 1; 19 (5): 791-5.

    AbstractPatients receiving chemotherapy continue to experience nausea and vomiting despite recent strides to understand the physiology of these symptoms and despite current antiemetic therapies. Ondansetron, a serotonin antagonist, has shown to be a safe and effective drug in alleviating nausea and vomiting. This research-synthesis article provides summaries of eight clinical trials completed between 1988 and 1991. It includes a discussion of the pharmacodynamics and pharmacokinetics of ondansetron, suggestions for adverse events, and implications for nursing practice and future research.

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