• Julio Delgado, Nichola Cooper, Kirsty Thomson, Rafael Duarte, Michael Jarmulowicz, Anna Cassoni, Panagiotis Kottaridis, Karl Peggs, and Stephen Mackinnon.
• Department of Hematology, Royal Free & University College Medical School, London, United Kingdom. julio.delgado@heartofengland.nhs.uk
• Biol. Blood Marrow Transplant. 2006 Jan 1; 12 (1): 75-83.

AbstractNonmalignant late effects, including chronic renal failure (CRF), impair the quality of life of long-term survivors after allogeneic hematopoietic cell transplantation. One of the major risk factors is the use of total body irradiation (TBI) in the preparative regimen; TBI is currently fractionated in an attempt to reduce toxicity. We analyzed 241 patients who had TBI-based preparative regimens for allogeneic hematopoietic cell transplantation. TBI was delivered as a single fraction of 7.5 Gy (7.5S group), 12 Gy in 6 fractions (12F group), or 14.4 Gy in 8 fractions (14.4F group). The cumulative incidence of CRF at 2 years was 12%. Statistical analysis revealed that older age (P < .001) and fludarabine administration (P = .016) had a significant effect on the incidence of CRF. Furthermore, single-fraction TBI was also significantly associated with CRF severity, because 7 (6.3%) of 111 patients in the 7.5S group developed severe CRF, as opposed to 1 (0.8%) of 130 patients in the 12F and 14.4F groups combined (P = .044). However, these conclusions should be regarded as preliminary in view of the retrospective and nonrandomized nature of this study.

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