• Oguzhan Kuru, Ilker Cakır, Utku Akgor, Serhat Sen, Goksen Gorgulu, Hasan Emre Ozdemir, Banu Isbilen Basok, Goksever Akpınar, and Mehmet Gokcu.
• Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey.
• Int. J. Clin. Pract. 2021 Nov 1; 75 (11): e14609.

ObjectiveTo analyse the serum markers for the early diagnosis of intestinal anastomotic leak (AL) after the gyne-oncological operations.MethodsBetween September 2017 and March 2021, patients with an intestinal anastomosis performed during the gyne-oncological surgeries were identified from a tertiary centre in Turkey. As the local guideline of the clinic, all these patients were followed by measuring serum samples including procalcitonin (PCT) and C-reactive protein (CRP) on postoperative day (POD) 1 through the day of discharge or the day of re-operation for AL.Results12.5% (5/40) of the patients suffered an AL and 4 of them were re-operated. The mean albumin values on POD 3-4 and the mean platelet values on POD 1 were lower in the AL group (P < .05). Although it was not statistically significant (P > .05), median PCT values (ng/mL) on POD 8-10 were higher in the AL group compared with no leak group. The best cut-off point for PCT on POD 9 was determined to be 0.11 ng/mL (AUC: 0.917, Sensitivity = 100.0%, specificity = 66.7%, positive predictive value = 66.7%, negative predictive value = 100.0%).ConclusionSerum PCT and CRP concentrations were not found to be helpful for the early diagnosis of AL in patients operated for gyne-oncological malignancies. Low levels of albumin and platelets in the first days after the operation may be clue for a possible AL.© 2021 John Wiley & Sons Ltd.

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