• Yu Wang, Karey Shumansky, Don D Sin, S F Paul Man, Loubna Akhabir, John E Connett, Nicholas R Anthonisen, Peter D Paré, Andrew J Sandford, and Jian-Qing He.
• Department of Respiratory and Critical Medicine, West China Hospital of Sichuan University Chengdu, Sichuan Province, China.
• Int J Clin Exp Patho. 2015 Jan 1; 8 (10): 13125-35.

ObjectiveWe reported association of haplotypes formed by IL-1b (IL1B)-511C/T (rs16944) and a variable number of tandem repeats (rs2234663) in intron 3 of IL-1 receptor antagonist (IL1RN) with rate of lung function decline in smoking-induced COPD. The aim of current study was to further investigate this association.MethodsWe genotyped an additional 19 polymorphisms in IL1 cluster (including IL1A, IL1B and IL1RN) in non-Hispanic whites who had the fastest (n = 268) and the slowest (n = 292) decline of FEV1% predicted in the same study. We also analyzed the association of all 21 polymorphisms with serum CRP levels.ResultsNone of 21 polymorphisms showed significant association with rate of decline of lung function or CRP levels after adjusting for multiple comparisons. Before adjusting for multiple comparisons, only IL1RN_19327 (rs315949) showed significant association with lung function decline (P = 0.03, additive model). The frequencies of genotypes containing the IL1RN_19327A allele were 71.9% and 62.2%, respectively in the fast and slow decline groups (P = 0.02, odds ratio = 1.6, 95% confidence interval = 1.1-2.3); the IL1B_5200 (rs1143633) and rs2234663 in IL1RN were associated with serum CRP levels (P=0.04 and 0.03, respectively).ConclusionsNo single marker was significantly associated with either rate of lung function decline or serum CRP levels.

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