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Cancer Chemother. Pharmacol. · Nov 2001
Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice.
- H S Friedman, S T Keir, P J Houghton, A A Lawless, D D Bigner, and S J Waters.
- Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
- Cancer Chemother. Pharmacol. 2001 Nov 1; 48 (5): 413-6.
PurposeThis study was conducted to define the activity of irofulven in the treatment of a series of xenografts derived from human glioblastoma multiforme growing subcutaneously and intracranially in athymic nude mice.MethodsAthymic mice bearing subcutaneous or intracranial tumors were treated with irofulven at a 10% lethal dose with responses compared to tumor-bearing mice treated with drug vehicle.ResultsIrofulven was active against all tumor lines tested with growth delays ranging from 5.6 to 81.6 days (all values statistically significant, P < or = 0.001). Irofulven also produced a statistically significant (P < or = 0.001) increase in the median survival of mice bearing D-456 intracranial xenografts with a 162% increase in median survival.ConclusionsIrofulven is active in a spectrum of human glioblastoma multiforme-derived xenografts and evaluation in patients with this neoplasm is warranted.
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