• Critical care medicine · Apr 1981

    Mechanism of action of epinephrine in resuscitation from asphyxial arrest.

    • C W Otto, R W Yakaitis, and C D Blitt.
    • Crit. Care Med. 1981 Apr 1; 9 (4): 321-4.

    AbstractTo determine the relative importance of the alpha and beta adrenergic effects of epinephrine in resuscitation, 32 dogs were studied in four groups. Group A (alpha blocked) received phenoxybenzamine, 70 mg/kg; group B (beta blocked), propranolol 5 mg/kg; group C (alpha and beta blocked) both drugs; and group D (control), no drug. After this treatment and 5 min of asphyxial arrest, all animals received closed chest cardiac massage (CCCM), artificial ventilation (AR), and epinephrine, 1 mg, iv. Resumption of spontaneous circulation occurred with the following frequency: group A, 0/8; group B, 6/8, group C, 0/8, group D, 7/8. The difference in successful resuscitation of the alpha blocked animals and the not alpha blocked animals is statistically significant (P less than or equal to 0.01). It is concluded that the efficacy of epinephrine in aiding resumption of spontaneous circulation from asphyxial arrest is due to alpha adrenergic receptor stimulation and that beta receptor stimulation is not important in determining outcome.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…