• Hwa-Shin Fang, Chun-Chieh Wang, Chih-Ying Chao, Wen-Lang Fan, Shih-Chi Su, and Yih-Ru Wu.
• Division of General Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taiwan.
• J Formos Med Assoc. 2022 Mar 1; 121 (3): 679-686.

Background/PurposeGenetic and environmental factors play significant roles in the pathogenesis of Parkinson's disease (PD). Recently, 17 novel risk loci of PD were identified in a meta-analysis of genome-wide association study (GWAS) in the European populations. In order to clarify if these risk loci are associated with PD in Taiwanese population, we conducted a case-control study including 14 of the novel risk loci and analyzed the genetic distribution and allele frequency.MethodsA total of 2798 subjects were recruited in this study. Genotyping was performed in 672 PD patients and 609 healthy controls by using Mass ARRAY, and data of another 1517 healthy controls from Taiwan Biobank were also examined.ResultsOur results show that the dominant models of ITPKB rs4653767 (OR (95% CI) = 0.832 (0.699, 0.990), p = 0.038), IL1R2 rs34043159 (OR (95% CI) = 0.812 (0.665, 0.992), p = 0.041) and COQ7 rs11343 (OR (95% CI) = 0.304 (0.180, 0.512), p < 0.001) were associated with PD. In allelic analysis, the T allele of IL1R2 rs34043159 (OR (95% CI) = 0.873 (0.772, 0.987), p = 0.03) and T allele of COQ7 rs11343 (OR (95% CI) = 0.098 (0.040, 0.238), p < 0.001) showed lower risk of PD. After Bonferroni correction, only dominant model and T allele of COQ7 rs11343 showed significantly reduced the risk of PD.ConclusionThis study suggests that ITPKB, IL1R2 and COQ7 have influence on the risk of PD in Taiwan.Copyright © 2021 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.

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