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Agents Actions Suppl. · Jan 1982
The influence of inhibitors of RNA and protein synthesis on dexamethasone action in carrageenin paw edema and adjuvant arthritis of rats.
- R Hirschelmann, R Schade, and H Bekemeier.
- Agents Actions Suppl. 1982 Jan 1;10:233-40.
AbstractThe anti-inflammatory effect of dexamethasone in carrageenin paw edema and in adjuvant arthritis of rats was not influenced by simultaneous injection of RNA/protein synthesis inhibitors. The increase of the plasma alpha 2-microglobulin level during adjuvant arthritis was significantly reduced after administration of RNA/protein synthesis inhibitors. This inhibitory effect was abolished by simultaneous dexamethasone treatment. The present results do hardly support the hypothesis that the anti-inflammatory activity of dexamethasone and other glucocorticosteroids in carrageenin edema and adjuvant arthritis of rats might be mediated by de novo protein synthesis.
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