• Annals of hematology · Feb 2011

    High prevalence of hepatitis B and hepatitis C virus infections in Korean patients with hematopoietic malignancies.

    • Jun Kang, Jeong Hyun Cho, Cheol Won Suh, Dae Ho Lee, Heung Bum Oh, Yong Hak Sohn, Hyun Sook Chi, Chan Jeong Park, Sung Soo Jang, Kyoo Hyung Lee, Je-Hwan Lee, Jung Hee Lee, Sang Wook Lee, Young Hwa Chung, Tae Hyup Kim, Hai-Rim Shin, and Jooryung Huh.
    • Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnap-dong, Songpa-gu, Seoul, South Korea.
    • Ann. Hematol. 2011 Feb 1; 90 (2): 159-64.

    AbstractWe performed a large case-control study (3,932 cases, 15,562 controls) to investigate the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) with hematopoietic malignancies in Korea, where HBV is endemic. HBV was present in 636 control patients (4.1%), 333 lymphoma patients (12.4%), and 75 leukemia patients (6.0%). HCV infection was present in 173 control patients (1.1%), 76 lymphoma patients (2.8%), and 18 leukemia patients (1.4%). Co-infection of HBV and HCV was present in one (0.007%) control patient, seven lymphoma patients (0.3%), and one leukemia patient (0.08%). HBV infection was associated with increased risks for most subtypes of B and T/NK-cell lymphomas, Hodgkin's lymphoma, and acute myeloid leukemia. HCV infection was associated with increased risks for diffuse large B cell lymphoma, extranodal marginal zone B cell lymphoma, peripheral T cell lymphoma, and acute lymphoid leukemia B cell early pre-B type. HBV seems to have a more important role than HCV in the pathogenesis of specific hematologic malignancies in Korea.

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