• Mette Marklund, Søren Torp-Pedersen, Niels Bentzon, Carsten Thomsen, Anne Roslind, and Christian P Nolsøe.
• The Parker Institute, Frederiksberg Hospital, Ndr. Fasanvej 57-59, DK-2000 Frederiksberg, Denmark. mm@frh.regionh.dk
• Eur J Radiol. 2008 Feb 1; 65 (2): 279-85.

PurposeTo quantify the border versus centre enhancement of malignant breast tumours on dynamic magnetic resonance mammography.Materials And MethodsFifty-two women diagnosed with primary breast cancer underwent dynamic magnetic resonance mammography (Omniscan 0.2 mmol/kg bodyweight) on a midfield scanner (0.6 T), prior to surgery. The following five variables were recorded from the border and centre regions of the tumours: Early Enhancement, Time to Peak, Wash-in rate, Wash-out rate and Area under Curve. Information on histology type, oestrogen and progesterone receptor status was collected. Statistical analysis was performed in SAS 9.1 as paired samples t-tests.ResultsFifty of 52 malignant tumours displayed a faster Early Enhancement in the border region compared to the centre (p<0.0001). Significant differences between the border and centre values were found for Time to Peak, Wash-in rate, Wash-out rate and Area under Curve. Hormone receptor positive tumours displayed an over-all highly significant difference between border and centre enhancement, whereas no significant differences for any of the five variables were recorded in neither oestrogen nor progesterone hormone receptor negative tumours.ConclusionThe border/centre enhancement difference in malignant breast tumours is easily visualized on midfield dynamic magnetic resonance mammography. The dynamic behaviour is significantly correlated to histological features and receptor status of the tumours.

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