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- D J Duthie, A D McLaren, and W S Nimmo.
- Br J Anaesth. 1986 Sep 1; 58 (9): 950-6.
AbstractForty-five patients in four groups undergoing orthopaedic, upper abdominal, prolonged or cardiac surgery received a constant rate i.v. infusion of fentanyl 100 micrograms h-1, for 24 h starting 2 h before surgery. A single bolus dose was given i.v. at the induction of anaesthesia. Plasma fentanyl concentrations, measured by radioimmunoassay were between 1 and 3 ng ml-1 until the infusions were discontinued. Clearance of fentanyl was decreased in the cardiac surgery group only. The elimination half-life was 7.3-9.7 h. This simple regimen produced effective analgesia.
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