• Varuna Prakash, Jeffrey A Stainsby, Janakan Satkunasingham, Tim Craig, Charles Catton, Philip Chan, Laura Dawson, Jennifer Hensel, David Jaffray, Michael Milosevic, Alan Nichol, Marshall S Sussman, Gina Lockwood, and Cynthia Ménard.
• Department of Radiation Oncology, Princess Margaret Hospital, Toronto, ON, Canada.
• Int. J. Radiat. Oncol. Biol. Phys. 2008 Jul 15; 71 (4): 1253-60.

PurposeTo validate a correlation coefficient template-matching algorithm applied to the supervised automated quantification of abdominal-pelvic organ motion captured on time-resolved magnetic resonance imaging.Methods And MaterialsMagnetic resonance images of 21 patients across four anatomic sites were analyzed. Representative anatomic points of interest were chosen as surrogates for organ motion. The point of interest displacements across each image frame relative to baseline were quantified manually and through the use of a template-matching software tool, termed "Motiontrack." Automated and manually acquired displacement measures, as well as the standard deviation of intrafraction motion, were compared for each image frame and for each patient.ResultsDiscrepancies between the automated and manual displacements of > or =2 mm were uncommon, ranging in frequency of 0-9.7% (liver and prostate, respectively). The standard deviations of intrafraction motion measured with each method correlated highly (r = 0.99). Considerable interpatient variability in organ motion was demonstrated by a wide range of standard deviations in the liver (1.4-7.5 mm), uterus (1.1-8.4 mm), and prostate gland (0.8-2.7 mm). The automated algorithm performed successfully in all patients but 1 and substantially improved efficiency compared with manual quantification techniques (5 min vs. 60-90 min).ConclusionSupervised automated quantification of organ motion captured on magnetic resonance imaging using a correlation coefficient template-matching algorithm was efficient, accurate, and may play an important role in off-line adaptive approaches to intrafraction motion management.

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