• Breast Cancer Res. Treat. · May 2008

    Epidermal growth factor receptor (EGFR) and the estrogen receptor modulator amplified in breast cancer (AIB1) for predicting clinical outcome after adjuvant tamoxifen in breast cancer.

    • Looket Dihge, Pär-Ola Bendahl, Dorthe Grabau, Jorma Isola, Kristina Lövgren, Lisa Rydén, and Mårten Fernö.
    • Department of Oncology, Clinical Sciences, University of Lund, Lund, Sweden.
    • Breast Cancer Res. Treat. 2008 May 1; 109 (2): 255-62.

    AbstractThe epidermal growth factor receptor (EGFR) and the estrogen receptor (ER) modulator Amplified In Breast cancer-1 (AIB1) have been reported to be of importance for the prognosis of breast cancer patients. We have analyzed AIB1 and EGFR by immunohistochemistry in primary breast cancers (n = 297) arranged in a tissue microarray in order to predict outcome after adjuvant endocrine therapy with tamoxifen for two years. High expression of AIB1 was associated with DNA-nondiploidy, high S-phase fraction, HER2 amplification, and short term (

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