• Rinsho Ketsueki · Nov 1990

    [Infection prophylaxis in patients with hematological malignancies (I)--Successful prophylaxis of Pneumocystis carinii pneumonitis with sulfamethoxazole-trimethoprim].

    • Y Moriuchi, S Kamihira, T Satoh, T Yanagisako, Y Miyazaki, K Nagai, K Murata, S Tokunaga, T Maeda, and S Atogami.
    • Department of Internal Medicine, Nagasaki University School of Medicine.
    • Rinsho Ketsueki. 1990 Nov 1; 31 (11): 1818-22.

    AbstractIn a retrospective study to evaluate the efficacy of sulfamethoxazole-trimethoprim (SMX-TMP) for the prevention of Pneumocystis carinii pneumonitis, we studied 1760 patients wit hematological malignancies over a twenty-year period (1970-1989). 449 patients received oral SMX-TMP, most of all received 400 mg of SMX and 80 mg of TMP twice per day. None of the patients receiving SMX-TMP developed P carinii pneumonitis, whereas twenty-six (2.0%) of the 1311 patients who did not receive SMX-TMP developed P carinii pneumonitis (p less than 0.01). We found that the SMX-TMP was very effective in the prevention of P carinii pneumonitis in patients with hematological malignancies, and was well tolerated.

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