• Ligong Wang, Renata La Rocca Vieira, Leon D Rybak, James S Babb, Gregory Chang, Svetlana Krasnokutsky, Steven Abramson, and Ravinder Regatte.
• Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG), Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY 10016, USA; School of Radiation Medicine and Protection, Medical College of Soochow University; School for Radiological and interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, Jiangsu 215123, China. Electronic address: ligong.wang@hotmail.com.
• Eur J Radiol. 2013 Nov 1; 82 (11): 1946-52.

ObjectiveTo assess the relationship between knee alignment and subregional T1ρ values of the femorotibial cartilage and menisci in patients with mild (Kellgren-Lawrence grade 1) to moderate (KL3) osteoarthritis (OA) at 3T.Materials And Methods26 subjects with a clinical diagnosis of KL1-3 OA were included and subdivided into three subgroups: varus, valgus, and neutral. All subjects were evaluated on a 3T MR scanner. Mann-Whitney and Wilcoxon signed rank tests were performed to determine any statistically significant differences in subregional T1ρ values of femorotibial cartilage and menisci among the three subgroups of KL1-3 OA patients.ResultsMedial femoral anterior cartilage subregion in varus group had significantly higher (p<0.05) T1ρ values than all cartilage subregions in valgus group. Medial tibial central cartilage subregion had significantly higher T1ρ values (p<0.05) than lateral tibial central cartilage subregion in varus group. The posterior horn of the medial meniscus in neutral group had significantly higher T1ρ values (p<0.0029) than all meniscus subregions in valgus group.ConclusionThere exists some degree of association between knee alignment and subregional T1ρ values of femorotibial cartilage and menisci in patients with clinical OA.Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

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