• J Indian Med Assoc · May 2007

    Randomized Controlled Trial Comparative Study

    A study on the effects of diclofenac sodium and etoricoxib in the treatment of osteoarthritis.

    • S Ghosh, S Paul, N Das, and T K Bhattacharyya.
    • Department of Pharmacology, North Bengal Medical College, Darjeeling 734012.
    • J Indian Med Assoc. 2007 May 1; 105 (5): 260-2.

    AbstractDiclofenac sodium, a non-selective cyclo-oxygenase inhibitor and etoricoxib, a selective cyclo-oxygenase-2 inhibitor have been widely used in treatment of patients with osteo-arthritis. Five hundred and eighty-five patients with uncomplicated knee osteo-arthritis were randomly allocated into 3 equal groups and received either diclofenac sodium, etoricoxib or placebo in a double-blind manner. The response in both the drug groups was comparable and much more than placebo group. The study shows that etoricoxib provides better clinical efficacy and gastro-intestinal tolerability in osteo-arthritis in comparison to diclofenac sodium presumably due to the selective inhibition of cyclo-oxygenase-2 by etoricoxib.

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