• Chun-Chao Xia, Xi Liu, Wan-Lin Peng, Lei Li, Jin-Ge Zhang, Wen-Jian Meng, Xiang-Bing Deng, Pan-Li Zuo, and Zhen-Lin Li.
• Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China.
• Eur J Radiol. 2016 Oct 1; 85 (10): 1818-1823.

PurposeTo determine whether readout-segmented echo-planar imaging (rs-EPI) diffusion-weighted imaging (DWI) can improve the image quality in patients with rectal cancer compared with single-shot echo-planar imaging (ss-EPI) DWI using 3.0 T magnetic resonance (MR) imaging.Materials And MethodsThis study was approved by the Institutional Review Board, and informed consent was obtained from all patients. Seventy-one patients with rectal cancer were enrolled in this study. For all patients, both rs-EPI and ss-EPI DWI were performed using a 3T MR scanner. Two radiologists independently assessed the overall image quality, lesion conspicuity, geometric distortion and distinction of anatomical structures. The signal-to-noise ratio (SNR), lesion contrast, contrast-to-noise ratio (CNR), and apparent diffusion coefficient (ADC) were also measured. Comparisons of the quantitative and qualitative parameters between the two sequences were performed using the paired t-test and the Wilcoxon signed rank test.ResultsThe scores of overall image quality, lesion conspicuity, geometric distortion and distinction of anatomical structures of rs-EPI were all significantly higher than those of ss-EPI (all p<0.05). The SNR and CNR were higher in rs-EPI than those in ss-EPI (all p<0.05). There was no significant difference between ss-EPI and rs-EPI with regard to ROI size and mean ADCs of the tumour (p=0.574 and p=0.479, respectively), but the mean ADC of the normal tissue was higher in rs-EPI than in ss-EPI (1.73±0.30×10(-3)mm(2)/s vs. 1.60±0.31×10(-3)mm(2)/s, p=0.001).ConclusionsDW imaging based on readout-segmented echo-planar imaging is a clinically useful technique to improve the image quality for the purpose of evaluating lesions in patients with rectal tumours.Copyright © 2016. Published by Elsevier Ireland Ltd.

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