Functional proteomics can be defined as a strategy to couple proteomic information with biochemical and physiological analyses with the aim of understanding better the functions of proteins in normal and diseased organs. In recent years, a variety of publicly available bioinformatics databases have been developed to support protein-related information management and biological knowledge discovery. ⋯ Here, we present a comprehensive review of the major human protein bioinformatics databases. We conclude this review by discussing a few examples that illustrate the importance of these databases in functional proteomics research.
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Sci China Life Sci. 2011 Nov 1; 54 (11): 988-98.
AbstractFunctional proteomics can be defined as a strategy to couple proteomic information with biochemical and physiological analyses with the aim of understanding better the functions of proteins in normal and diseased organs. In recent years, a variety of publicly available bioinformatics databases have been developed to support protein-related information management and biological knowledge discovery. In addition to being used to annotate the proteome, these resources also offer the opportunity to develop global approaches to the study of the functional role of proteins both in health and disease. Here, we present a comprehensive review of the major human protein bioinformatics databases. We conclude this review by discussing a few examples that illustrate the importance of these databases in functional proteomics research.