• Hirokazu Tokuyasu, Tomoya Harada, Hirokazu Touge, Yuji Kawasaki, Ryo Maeda, Noritaka Isowa, Hideyuki Ohnuma, Hiroshi Miura, and Eiji Shimizu.
• Division of Respiratory Medicine, Matsue Red Cross Hospital, Matsue. tokuun3200@yahoo.co.jp
• Intern. Med. 2008 Jan 1; 47 (23): 2049-52.

AbstractA 51-year-old woman suffered from xerophthalmia and xerostomia for 3 years without being medically examined. In July 2006, she was referred to our hospital for the evaluation of chest roentgenogram showing slight pleural effusion in the right lung. A chest CT scan revealed multiple nodules, enlarged mediastinal and hilar lymph nodes, and bilateral slight pleural effusions. A diagnosis of Sjögren's syndrome was made on the basis of the results of sialography, lip biopsy, Schirmer's test, and elevated titer of antibody to SS-A antigen. Histological examination of the specimen from the nodular lesion by video-assisted thoracoscopic biopsy revealed noncaseating epithelioid cell granuloma containing giant cells, which confirmed the diagnosis of sarcoidosis. Although the coexistence of Sjögren's syndrome and sarcoidosis has been reported occasionally, cases with histological evidence of sarcoidosis have been rare. Pulmonary sarcoidosis should be considered in the differential diagnosis of pulmonary multiple nodules in patients with Sjögren's syndrome.

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