• Eur J Nucl Med · Jan 1999

    Comparative Study

    Role of attenuation correction for fluorine-18 fluorodeoxyglucose positron emission tomography in the primary staging of malignant lymphoma.

    • J Kotzerke, A Guhlmann, F Moog, N Frickhofen, and S N Reske.
    • Department of Nuclear Medicine, University of Ulm, Germany.
    • Eur J Nucl Med. 1999 Jan 1; 26 (1): 31-8.

    AbstractFluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) has been shown to improve the diagnostic accuracy in the staging of malignant lymphomas, based on the metabolic signal of the lesions. This study was undertaken to determine the effect of attenuation correction in the detection of nodal and extranodal lesions in the primary staging of malignant lymphomas. Fifty-one untreated patients with either non-Hodgkin lymphoma (NHL, n=29) or Hodgkin's disease (n=22) were retrospectively evaluated. Static FDG-PET imaging of the trunk was performed following administration of 250-350 MBq FDG. Attenuation correction was performed in all patients. Images were reconstructed iteratively with or without transmission scans. Image evaluation was performed independently by two observers, who each examined one set of images (i.e. attenuation-corrected or uncorrected). The final decision as to whether results were discordant was reached by consensus of both observers. Out of 593 evaluated lymph node regions, 187 regions of increased FDG uptake were identified by both techniques. Differences between the readers concerned mainly the anatomical assignment of lesions (n=33) or the status (benign/malignant) of individual lesions (n=24). However, direct comparison of the two sets of images demonstrated very similar lesion contrast on attenuation-corrected and non-attenuation-corrected images. Real differences could be determined only in five regions (neck, 1; mediastinum, 1; upper abdomen, 3). Thirty-seven extranodal lesions (including lung, liver, spleen, bone marrow and soft tissue) were detected by both techniques without significant differences. It is concluded that in this study, attenuation correction did not improve the diagnostic accuracy of FDG-PET in the detection of lymph node or organ involvement during the primary staging of malignant lymphomas. Of more importance seemed to be the experience of the reader regarding the classification of a lesion's status the anatomical assignment, knowledge of physiological uptake and artefacts, and systematic and skillful examination of all regions scanned.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.