• Michiel J Vanfleteren, Maud Koopman, Martijn A Spruit, Herman-Jan Pennings, Frank Smeenk, Willem Pieters, Jan J van den Bergh, Arent-Jan Michels, Emiel F Wouters, Miriam T Groenen, Frits M Franssen, and Lowie E Vanfleteren.
• Department of Research and Education, Center of Expertise for Chronic Organ Failure (CIRO), Horn, the Netherlands; Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands. Electronic address: michielvanfleteren@msn.com.
• Arch Phys Med Rehabil. 2018 Nov 1; 99 (11): 2279-2286.e3.

ObjectiveTo evaluate the effect of pulmonary rehabilitation (PR) on exercise performance and quality of life in patients with chronic obstructive pulmonary disease (COPD) with different degrees of static lung hyperinflation (LH).DesignRetrospective cohort study.SettingPR network.ParticipantsA cohort of 1981 patients with COPD (55% men; age: 66.8±9.3y; forced expiratory volume in the first second%: 50.7±19.5; residual volume [RV]%: 163.0±49.7).InterventionAn interdisciplinary PR program for patients with COPD consisting of 40 sessions.Main Outcome MeasuresParticipants were stratified into 5 quintiles according to baseline RV and were evaluated on the basis of pre- and post-PR 6-minute walk distance (6MWD), constant work rate test (CWRT), and Saint George's Respiratory Questionnaire (SGRQ), among other clinical parameters.ResultsWith increasing RV quintile, patients were younger, more frequently women, had lower forced expiratory volume in the first second%, lower body mass index and fat-free mass index, shorter 6MWD, shorter CWRT, and worse SGRQ scores (P<.01). All RV strata improved after PR in all 3 outcomes (P<.001). Nevertheless, higher, compared to lower RV categories, had lower ΔCWRT (P<.01) but similar Δ6MWD (P=.948) and ΔSGRQ (P=.086) after PR.ConclusionsLH in COPD is related to younger age, female sex, lower body weight, worse exercise capacity and health status, but did not prevent patients from benefitting from PR. LH, however, influences walking and cycling response after PR differently.Copyright © 2018 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

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