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- Yujie Jiang, Xin Wei, Jingjing Guan, Shuang Qin, Zhongyong Wang, Hong Lu, Jingjing Qian, Lianfeng Wu, Yingxiao Chen, Yanfan Chen, and Xiangyang Lin.
- Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
- Clin. Immunol. 2020 Sep 1; 218: 108516.
BackgroundCoronavirus disease 2019 (COVID-19) is posing a huge threat to human health worldwide. We aim to investigate the immune status of CD8+ T and NK cells in COVID-19 patients.MethodsThe count and immune status of lymphocytes were detected by flow cytometry in 32 COVID-19 patients and 18 healthy individuals.ResultsAs the disease progression in COVID-19 patients, CD8+ T and NK cells were significantly decreased in absolute number but highly activated. After patients' condition improved, the count and immune status of CD8+ T and NK cells restored to some extent. GrA+CD8+ T and perforin+ NK cells had good sensitivity and specificity for assisting diagnosis of COVID-19.ConclusionsAs the disease progression, the declined lymphocytes in COVID-19 patients might lead to compensatory activation of CD8+ T and NK cells. GrA+CD8+ T and perforin+ NK cells might be used as meaningful indicators for assisting diagnosis of COVID-19.Copyright © 2020. Published by Elsevier Inc.
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