• Critical care clinics · Oct 2006

    Review

    Advances in the management of seizures and status epilepticus in critically ill patients.

    • Karine J Abou Khaled and Lawrence J Hirsch.
    • Comprehensive Epilepsy Center, Department of Neurology, Columbia University Neurological Institute, New York, NY 10032, USA.
    • Crit Care Clin. 2006 Oct 1;22(4):637-59; abstract viii.

    AbstractSeizures and status epilepticus are common in critically ill patients. They can be difficult to recognize because most are non-convulsive and require electroencephalogram monitoring to detect; hence, they are currently underdiagnosed. Early recognition and treatment are essential to obtain maximal response to first-line treatment and to prevent neurologic and systemic sequelae. Anti-seizure medication should be combined with management of the underlying cause and reversal of factors that can lower the seizure threshold, including many medications, fever, hypoxia, and metabolic imbalances. This article discusses specific treatments and specific situations, such as hepatic and renal failure patients and organ transplant patients.

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