• Min Li, Ming-hui Yang, and Yi Liu.
• Institute of Traditional Chinese Medicine, General Hospital of the People's Liberation Army, Beijing 100853, China. kittenlee1115@126.com
• Zhong Xi Yi Jie He Xue Bao. 2012 Mar 1; 10 (3): 310-7.

BackgroundThe main clinical symptoms of Parkinson disease (PD) are resting tremor, muscle rigidity and bradykinesia. There is currently no effective treatment for PD, and dyskinesia symptoms affect the quality of life of patients with PD. The Chinese medicine therapy used for reinforcing kidney and activating blood circulation in treatment of PD was reported to achieve good clinical effects.ObjectiveTo study the effects of Bushen Huoxue Granule, a compound traditional Chinese herbal medicine, on the quality of life of patients with PD.Design, Setting, Participants And InterventionsA total of 120 patients were enrolled from General Hospital of the People's Liberation Army in China and divided into two groups randomly. Patients in the control group were treated with a placebo and in the treatment group with Bushen Huoxue Granule based on treating with levodopa. A double-blinded clinical trial was adopted over a 3-month treatment with a follow-up period lasting 6 months.Main Outcome MeasuresUnified Parkinson Disease Rating Scale II (UPDRS II), questionnaire-39 (PDQ-39) and Parkinson's disease sleep scale (PDSS) were adopted to measure the quality of life at baseline, after 3 months of treatment and at a 6-month follow-up.ResultsBushen Huoxue Granule showed a higher efficacy than the control in improving life quality of patients with PD by improving scores of UPDRS II, PDQ-39 and PDSS (P<0.05). No adverse effects were found in this trial.ConclusionBushen Huoxue Granule can markedly improve the quality of life of patients with PD.

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