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Arterioscler. Thromb. Vasc. Biol. · Nov 2020
ReviewCOVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions.
- Shari B Brosnahan, Annemijn H Jonkman, Matthias C Kugler, John S Munger, and David A Kaufman.
- Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, NYU School of Medicine (S.B.B., M.C.K., J.S.M., D.A.K.).
- Arterioscler. Thromb. Vasc. Biol. 2020 Nov 1; 40 (11): 2586-2597.
AbstractThe severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions.
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