• Safora Johansen, Mathilde H Norman, Einar Dale, Cecilie D Amdal, Torbjørn Furre, Eirik Malinen, and Jan F Evensen.
• Department of oncology, Division of cancer Medicine, Surgery and Transplantation (KKT), Oslo University Hospital-Radium hospital, Montebello, 0310, Oslo, Norway. Safora.johansen@hioa.no.
• Radiat Oncol. 2017 May 25; 12 (1): 87.

AimTo evaluate the patterns of loco-regional recurrences in head and neck cancer patients METHODS: Twenty-six out of 112 patients treated with primary or postoperative 3D CRT or IMRT for their primary and recurrent disease between 2007 and 2013 were included. The CT images of recurrent disease were rigidly registered with the primary CT images for each patient. To assess overlaps and overlap localization, the recurrence volume overlapping with the primary target volume was identified. For relapses occurring in the regional lymph nodes, the epicenter distance in recurrences and primary volumes and dose in recurrences were also identified. The recurrences were defined as in-field, marginal or out-of-field.ResultsThe majority of the failures occurred within 1 year after completed primary treatment. The dose differences in recurrence volume were not statistically significant when patients were treated with IMRT or 3D CRT. Recurrence in 15/26 of the included patients occurred in the regional lymph nodes located fully or partly inside the primary target volume or the elective lymph node region. The majority of recurrences were recognized as in-field, independent of the primary treatment.ConclusionRecurrence in the majority of the patients occurred in the regional lymph nodes located in high dose area. The cause of recurrence may be due to inadequate total dose in the primary treatment and/or lack of optimal primary diagnosis leading to inadequate primary target delineation.

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