• A Baraka, N Kawkabani, A Dabbous, and M Nawfal.
• Department of Anesthesiology, American University of Beirut, Lebanon.
• J. Cardiothorac. Vasc. Anesth. 2000 Oct 1; 14 (5): 531-3.

ObjectiveTo determine the efficacy of a bolus of lidocaine administered by way of the pump before releasing the aortic cross-clamp (ACC) in preventing the occurrence of reperfusion ventricular fibrillation.DesignProspective, randomized study.SettingUniversity hospital.ParticipantsPatients undergoing coronary artery bypass graft surgery (n = 34).InterventionsSeventeen patients received 100 mg of lidocaine by way of the pump 2 minutes before releasing the ACC, and a control group of 17 patients received 5 mL of normal saline.Measurements And Main ResultsIn the control group, the incidence of reperfusion ventricular fibrillation was 70%, which was significantly decreased to 11% in the lidocaine group. A higher cardiac output after weaning from cardiopulmonary bypass was observed in the lidocaine group; this may be attributed to the lower incidence of reperfusion ventricular fibrillation and consequently the lower need for defibrillation by electric countershocks.ConclusionsThe results suggest that a bolus of 100 mg of lidocaine administered 2 minutes before release of the ACC can safely decrease the incidence of reperfusion ventricular fibrillation and is associated with better hemodynamics after weaning from cardiopulmonary bypass.

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