• Cancer discovery · Feb 2016

    Checkpoint Inhibitors Boost Power of Antibody-Drug Conjugate.

    • Cancer Discov. 2016 Feb 1; 6 (2): OF3.

    AbstractThe antibody-drug conjugate T-DM1 spurs immune cells to infiltrate HER2-positive breast tumors in patients. Treating mice that carry breast tumors with T-DM1 improves survival, but the tumors suppress the infiltrating lymphocytes. Combining T-DM1 with checkpoint inhibitors that block CTLA-4 and PD-1 overcomes this effect, eliminating breast tumors from 95% of the mice. ©2015 American Association for Cancer Research.

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