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Arch. Pathol. Lab. Med. · Oct 2012
ReviewStrategies for overcoming acquired resistance to epidermal growth factor receptor: targeted therapies in lung cancer.
- Geoffrey R Oxnard.
- Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02215, USA. Geoffrey_Oxnard@DFCI.harvard.edu
- Arch. Pathol. Lab. Med. 2012 Oct 1; 136 (10): 1205-9.
AbstractAcquired resistance to targeted therapy in epidermal growth factor receptor (EGFR)-mutant lung cancer represents a valuable model for considering strategies of overcoming different types of cellular resistance mechanisms. Using existing data on resistance in EGFR-mutant lung cancer, this review will discuss 3 basic approaches for overcoming resistance to EGFR-targeted therapies: intensification of EGFR inhibition, combination of EGFR inhibitors with other targeted therapies, and changing to anticancer therapies acting via alternate pathways.
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