• Marie Smedberg, Johan Helleberg, Åke Norberg, Inga Tjäder, Olav Rooyackers, and Jan Wernerman.
• Department of Anaesthesiology and Intensive Care, CLINTEC, Karolinska Institutet and Perioperative Medicine and Intensive Care, Karolinska University Hospital Huddinge Stockholm, B31 Perioperative Medicine and Intensive Care, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden. marie.smedberg@ki.se.
• Crit Care. 2021 Jul 7; 25 (1): 240.

BackgroundA plasma glutamine concentration outside the normal range at Intensive Care Unit (ICU) admission has been reported to be associated with an increased mortality rate. Whereas hypoglutaminemia has been frequently reported, the number of patients with hyperglutaminemia has so far been quite few. Therefore, the association between hyperglutaminemia and mortality outcomes was studied in a prospective, observational study.Patients And MethodsConsecutive admissions to a mixed general ICU were eligible. Exclusion criteria were < 18 years of age, readmissions, no informed consent, or a 'do not resuscitate' order at admission. A blood sample was saved within one hour from admission to be analysed by high-pressure liquid chromatography for glutamine concentration. Conventional risk scoring (Simplified Acute Physiology Score and Sequential Organ Failure Assessment) at admission, and mortality outcomes were recorded for all included patients.ResultsOut of 269 included patients, 26 were hyperglutaminemic (≥ 930 µmol/L) at admission. The six-month mortality rate for this subgroup was 46%, compared to 18% for patients with a plasma glutamine concentration < 930 µmol/L (P = 0.002). A regression analysis showed that hyperglutaminemia was an independent mortality predictor that added prediction value to conventional admission risk scoring and age.ConclusionHyperglutaminemia in critical illness at ICU admission was an independent mortality predictor, often but not always, associated with an acute liver condition. The mechanism behind a plasma glutamine concentration outside normal range, as well as the prognostic value of repeated measurements of plasma glutamine during ICU stay, remains to be investigated.

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