• Internal medicine · Jun 2021

    Case Reports

    Peg-IFNα-2a Contributed to HBs Antigen Seroclearance in a Patient with Chronic Hepatitis B Administered Nucleic Acid Analogs: A Three-year Follow-up.

    • Tomoko Tadokoro, Koji Fujita, Kei Takuma, Mai Nakahara, Kyoko Oura, Shima Mimura, Teppei Sakamoto, Takako Nomura, Joji Tani, Asahiro Morishita, Hirohito Yoneyama, Hideki Kobara, Takashi Himoto, and Tsutomu Masaki.
    • Department of Gastroenterology and Neurology, Kagawa University School of Medicine/Graduate School of Medicine, Japan.
    • Intern. Med. 2021 Jun 15; 60 (12): 1835-1838.

    AbstractWe treated a 51-year-old Japanese man with chronic hepatitis B (viral load 7.6 LC/mL, genotype C). Hepatitis B virus DNA and HBe antigen were undetectable during the administration of the nucleic acid analogs (NUCs) lamivudine and adefovir, although the concentration of HBs antigen (HBsAg) was 851.2 IU/mL. The HBsAg levels were reduced 150-fold when pegylated-interferon (Peg-IFN) α-2a was administered weekly for 48 weeks and did not increase during the rest period. Therefore, Peg-IFNα-2a was administered twice each week. During this time, HBsAg reached undetectable concentrations, and HBs antibody was detected and continued to be detectable during the three-year follow-up. These unprecedented findings suggest that IFN may contribute to the seroclearance of HBsAg in patients treated with NUCs.

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