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- Pritmohinder S Gill, Feliciano B Yu, Patricia A Porter-Gill, Bobby L Boyanton, Judy C Allen, Jason E Farrar, Aravindhan Veerapandiyan, Parthak Prodhan, Kevin J Bielamowicz, Elizabeth Sellars, Andrew Burrow, Joshua L Kennedy, Jeffery L Clothier, David L Becton, Don Rule, and G Bradley Schaefer.
- Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.
- J Pers Med. 2021 May 11; 11 (5).
AbstractPharmacogenomics (PGx) is a growing field within precision medicine. Testing can help predict adverse events and sub-therapeutic response risks of certain medications. To date, the US FDA lists over 280 drugs which provide biomarker-based dosing guidance for adults and children. At Arkansas Children's Hospital (ACH), a clinical PGx laboratory-based test was developed and implemented to provide guidance on 66 pediatric medications for genotype-guided dosing. This PGx test consists of 174 single nucleotide polymorphisms (SNPs) targeting 23 clinically actionable PGx genes or gene variants. Individual genotypes are processed to provide per-gene discrete results in star-allele and phenotype format. These results are then integrated into EPIC- EHR. Genomic indicators built into EPIC-EHR provide the source for clinical decision support (CDS) for clinicians, providing genotype-guided dosing.
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